Personal Information
Afonso C. Silva
Unit Head
NIH, NINDS, LFMI-10 Center Drive
Bldg. 10, Rm. B1D106, MSC 1065
Bethesda, MD 20892-1065
Phone: (301)402-9703
FAX: (301)480-2558
Email: SilvaA at ninds.nih.gov 		Personal photo is missing

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Personal History
Current Research Interests
Recent Publications
Curriculum Vitae or Resume

Personal History
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Afonso C. Silva was born on October 7, 1967, in Sao Paulo, Brazil.
He has B.S. (1990) and M.S. (1992) degrees in Electrical Engineering
from Universidade Federal de Pernambuco (UFPE), in Recife, Brazil.

In the Fall of 1992, Dr. Silva joined Dr. Alan Koretsky's lab at
Carnegie Mellon University, in Pittsburgh, PA, to work on the
Arterial Spin Labeling model to map and quantify cerebral blood
flow. Dr. Silva earned his Ph.D. degree in Biomedical Engineering in 
September of 1996. His thesis, entitled 'NMR Measurements of Rat
Brain Perfusion Using Arterial Spin Labeling', made fundamental 
contributions to the development of the Arterial Spin Labeling
method to measure CBF non-invasively using MRI.

In 1997, Dr. Silva joined the laboratory of Dr. Seong-Gi Kim in the
Center for Magnetic Resonance Research at the University of
Minnesota, in Minneapolis, MN. At the CMRR, Dr. Silva was able to
implement the Arterial spin Labeling technique in a rodent
functional brain activation model to study the spatial and temporal
characteristics of CBF changes during increased neuronal activity.

In 1999, Dr. Silva came to NINDS to continue his research on
cerebral blood flow regulation during functional neuronal activity.
He became a principal investigator and head of the Cerebral
Microcirculation Unit in 2004. 

Dr. Silva lives in Germantown with his wife and two children.

Current Research Interests
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  • The mechanisms of Cerebral Blood Flow (CBF) regulation
  • The mechanisms of functional MRI of brain activity, in particular related to measurements of CBF and of blood oxygenation level dependent (BOLD) induced responses to neural activity at high temporal and spatial resolution
  • Methods for three-dimensional high spatial resolution images of the brain
  • Two-photon laser scanning microscopy measurements of cortical microvasculature

Recent Publications in LFMI
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  1. A.C. Silva, F.F. Paiva
    Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling, Methods in Molecular Biology 489: 277-295(2009)
    2. Link to PubMed
  2. J. Tucciarone, K. Chuang, S.J. Dodd, A.C. Silva, G. Pelled, A.P. Koretsky
    Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI, NeuroImage 44: 923-931(2009)
    3. Link to PubMed
  3. K. Chuang, J. Lee, A.C. Silva, L. Belluscio, A.P. Koretsky
    Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli, NeuroImage 44: 363-372(2009)
    4. Link to PubMed
  4. N.A. Bock, A.C. Silva
    Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex, NMR in Biomedicine : -(2009)
    5. Link to PubMed
  5. J. Lee, M. Fukunaga, A.C. Silva, J.H. Duyn
    On the contribution of deoxy-hemoglobin to MRI gray-white matter phase contrast at high field, NeuroImage 7: 17-17(2009)
    6. Link to PubMed
  6. F.F. Paiva, A. Tannus, L.S. Talagala, A.C. Silva
    Arterial spin labeling of cerebral perfusion territories using a separate labeling coil, Journal of Magnetic Resonance Imaging 27: 970-977(2008)
    7. Link to PubMed
  7. A.G. Goloshevsky, A.C. Silva, S.J. Dodd, A.P. Koretsky
    BOLD fMRI and somatosensory evoked potentials are well correlated over a broad range of frequency content of somatosensory stimulation of the rat forepaw, Brain Research 1195: 67-76(2008)
    8. Link to PubMed
  8. N.A. Bock, F.F. Paiva, G.C. Nascimento, J.D. Newman, A.C. Silva
    Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI, Brain Research 1198: 160-170(2008)
    9. Link to PubMed
  9. A.C. Silva, J. Lee, C.W. Wu, J. Tucciarone, G. Pelled, I. Aoki, A.P. Koretsky
    Detection of cortical laminar architecture using manganese-enhanced MRI, Journal of Neuroscience Methods 167: 246-257(2008)
    10. Link to PubMed
  10. N.A. Bock, F.F. Paiva, A.C. Silva
    Fractionated manganese-enhanced MRI, NMR in Biomedicine 21: 473-478(2008)
    11. Link to PubMed
  11. B. Stefanovic, E. Hutchinson, V. Yakovleva, V. Schram, J.T. Russell, L. Belluscio, A.P. Koretsky, A.C. Silva
    Functional reactivity of cerebral capillaries, Journal of Cerebral Blood Flow and Metabolism 28: 961-972(2008)
    12. Link to PubMed
  12. A.C. Silva, N.A. Bock
    Manganese-enhanced MR, Schizophrenia Bulletin 34: 595-604(2008)
    13. Link to PubMed
  13. A.C. Silva, A.P. Koretsky, J.H. Duyn
    Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex, Magnetic Resonance in Medicine 57: 1110-1118(2007)
    14. Link to PubMed
  14. S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky
    BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system, Magnetic Resonance in Medicine 55: 316-324(2006)
    15. Link to PubMed
  15. I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. Koretsky
    Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride, NMR in Biomedicine 19: 50-59(2006)
    16. Link to PubMed
  16. B. Stefanovic, F. Bosetti, A.C. Silva
    Modulatory Role of Cylcooxygenase-2 in Cerebrovasular Coupling, NeuroImage 32: 23-32(2006)
    17. Link to PubMed
  17. Z. Chen, A.C. Silva, J. Yang, J. Shen
    Elevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA transaminase, Journal of Neuroscience Research 79: 383-391(2005)
    18. Link to PubMed
  18. J. Lee, A.C. Silva, H. Merkle, A.P. Koretsky
    Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast, Magnetic Resonance in Medicine 53: 640-648(2005)
    19. Link to PubMed
  19. A.P. Koretsky, L.S. Talagala, S.D. Keilholz, A.C. Silva
    MRI detection of regional blood flow using arterial spin labeling, Cambridge University Press : 119-140(2005)
  20. A.C. Silva
    Perfusion-based fMRI: insights from animal models,  Journal of Magnetic Resonance Imaging 22: 745-750(2005)
    21. Link to PubMed
  21. J.A. de Zwart, A.C. Silva, P. van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A.P. Koretsky, J.A. Frank, J.H. Duyn
    Temporal dynamics of the BOLD fMRI impulse response, NeuroImage 24: 667-677(2005)
    22. Link to PubMed
  22. S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky
    Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging, Magnetic Resonance in Medicine 52: 89-99(2004)
    23. Link to PubMed
  23. I. Aoki, Y.L. Wu, A.C. Silva, R.M. Lynch, A.P. Koretsky
    In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI, NeuroImage 22: 1046-1059(2004)
    24. Link to PubMed
  24. A.C. Silva, J. Lee, I. Aoki, A.P. Koretsky
    Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations,  NMR in Biomedicine 17: 532-543(2004)
    25. Link to PubMed
  25. A.P. Koretsky, A.C. Silva
    Manganese-enhanced magnetic resonance imaging (MEMRI), NMR in Biomedicine 17: 527-531(2004)
    26. Abstract   PDF Full Text
  26. A.C. Silva, H. Merkle
    Hardware considerations for functional magnetic resonance imaging, Concepts in Magnetic Resonance Part A: Magnetic Resonance Engineering 16: 35-49(2003)
  27. K.A. Hinds, J.M. Hill, E.M. Shapiro, M.O. Laukkanen, A.C. Silva, C.A. Combs, T.R. Varney, R.S. Balaban, A.P. Koretsky, D.E. Cynthia
    Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells, Blood 102: 144-156(2003)
    28. Link to PubMed
  28. C. Grabill, A.C. Silva, S.S. Smith, A.P. Koretsky, T.A. Rouault
    MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice, Brain Research 971: 144-156(2003)
    29. Link to PubMed
  29. S.J. Dodd, D.S. Williams, C. Olsen, A.C. Silva, A.P. Koretsky, C. Ho
    An open transverse z-gradient coil designs for magnetic resonance imaging, Rev. Sci. Instru. 73: 2208-2210(2002)
  30. I. Aoki, C. Tanaka, T. Takegami, T. Ebisu, M. Umeda, M. Fukunaga, K. Fukuda, A.C. Silva, A.P. Koretsky, S. Naruse
    Dynamic Activity-Induced Manganese-Dependent Contrast Magnetic Resonance Imaging (DAIM MRI), Magnetic Resonance in Medicine 48: 144-156(2002)
    31. Link to PubMed
  31. A.C. Silva, A.P. Koretsky
    Laminar Specificity of fMRI Onset Times During Somatosensory Stimulation in the Rat, Proc. Natl. Acad. Sci. 99: 144-156(2002)
    32. Link to PubMed
  32. E.L. Barbier, A.C. Silva, S. Kim, A.P. Koretsky
    Perfusion Imaging Using Dynamic Arterial Spin Labeling(DASL), Magnetic Resonance in Medicine 45: 144-156(2001)
    33. Link to PubMed
  33. E.L. Barbier, A.C. Silva, H. Kim, D. Will, A.P. Koretsky
    Perfusion Analysis Using Dynamic Arterial Spin Labeling, Magnetic Resonance in Medicine 41: 144-156(1999)
    34. Link to PubMed
  34. A.C. Silva, S. Kim
    Pseudo-continuous arterial spin labeling technique for measuring CBF dynamics with high temporal resolution, Magnetic Resonance in Medicine 42: 144-156(1999)
    35. Link to PubMed

Curriculum Vitae ro Resume
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