Personal Information
Alan P. Koretsky
Laboratory Chief
NIH, NINDS, LFMI-10 Center Drive
Bldg. 10, Rm. B1D728, MSC 1065
Bethesda, MD 20892-1065
Phone: (301)402-9659
FAX: (301)480-2558
Email: koretskya at ninds.nih.gov 		Personal photo is missing

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Personal History
Current Research Interests
Recent Publications
Curriculum Vitae or Resume

Personal History
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Dr. Koretsky received his B. S. degree from the Massachusetts 
Institute of Technology and Ph.D. from the University of California 
at Berkeley. He performed postdoctoral work in the NHLBI at NIH 
studying regulation of mitochondrial metabolism using optical and 
NMR techniques. Dr. Koretsky spent twelve years on the faculty in 
the Department of Biological Sciences at Carnegie Mellon University 
where he was the Eberly Professor of Structural Biology and 
Chemistry. In summer 1999, he moved to NINDS as Chief of the 
Laboratory of Functional and Molecular Imaging and Director of the 
NIH MRI Research Facility.

Current Research Interests
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  • Anatomical, functional and molecular imaging of the brain
  • Cellular energy metabolism, role of creatine kinase, mitochondrial proteomics
  • Mouse Imaging, imaging to aid functional genomics

Recent Publications in LFMI
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  1. K. Chuang, A.P. Koretsky
    Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging, Magnetic Resonance in Medicine : -(2009)
    2. Link to PubMed
  2. J.P. Sumner, E.M. Shapiro, D. Maric, R. Conroy, A.P. Koretsky
    In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxid, NeuroImage 44: 671-678(2009)
    3. Link to PubMed
  3. J. Tucciarone, K. Chuang, S.J. Dodd, A.C. Silva, G. Pelled, A.P. Koretsky
    Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI, NeuroImage 44: 923-931(2009)
    4. Link to PubMed
  4. K. Chuang, J. Lee, A.C. Silva, L. Belluscio, A.P. Koretsky
    Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli, NeuroImage 44: 363-372(2009)
    5. Link to PubMed
  5. A.G. Goloshevsky, A.C. Silva, S.J. Dodd, A.P. Koretsky
    BOLD fMRI and somatosensory evoked potentials are well correlated over a broad range of frequency content of somatosensory stimulation of the rat forepaw, Brain Research 1195: 67-76(2008)
    6. Link to PubMed
  6. E.M. Shapiro, A.P. Koretsky
    Convertible manganese contrast for molecular and cellular MRI, Magnetic Resonance in Medicine 60: 265-269(2008)
    7. Link to PubMed
  7. A.C. Silva, J. Lee, C.W. Wu, J. Tucciarone, G. Pelled, I. Aoki, A.P. Koretsky
    Detection of cortical laminar architecture using manganese-enhanced MRI, Journal of Neuroscience Methods 167: 246-257(2008)
    8. Link to PubMed
  8. B. Stefanovic, E. Hutchinson, V. Yakovleva, V. Schram, J.T. Russell, L. Belluscio, A.P. Koretsky, A.C. Silva
    Functional reactivity of cerebral capillaries, Journal of Cerebral Blood Flow and Metabolism 28: 961-972(2008)
    9. Link to PubMed
  9. J.H. Duyn, A.P. Koretsky
    Magnetic resonance imaging of neural circuits, Nat Clin Pract Cardiovasc Med 5: S71-S78(2008)
    10. Link to PubMed
  10. C. Sotak, K. Sharer, A.P. Koretsky
    Manganese cell labeling of murine hepatocytes using manganese(III)-transferrin, Contrast Media & Molecular Imaging 3: 95-105(2008)
    11. Link to PubMed
  11. J.M. Simmons, Z.S. Saad, M.J. Lizak, M. Ortiz, A.P. Koretsky, B.J. Richmond
    Mapping prefrontal circuits in vivo with manganese-enhanced magnetic resonance imaging in monkeys, Journal of Neuroscience Methods 28: 7637-7647(2008)
    12. Link to PubMed
  12. K. Chuang, P. van Gelderen, H. Merkle, J. Bodurka, V.N. Ikonomidou, A.P. Koretsky, J.H. Duyn, L.S. Talagala
    Mapping resting-state functional connectivity using perfusion MRI, NeuroImage 40: 1595-1605(2008)
    13. Link to PubMed
  13. G. Zabow, S.J. Dodd, J. Moreland, A.P. Koretsky
    Micro-engineered local field control for high-sensitivity multispectral MRI, Nature Neuroscience 453: 1058-1063(2008)
    14. Link to PubMed
  14. G. Goelman, G. Pelled, S.J. Dodd, A.P. Koretsky
    Tracking the effects of crusher gradients on gradient-echo BOLD signal in space and time during rat sensory stimulation, Magnetic Resonance in Medicine 60: 548-554(2008)
    15. Link to PubMed
  15. J.P. Sumner, R. Conroy, E.M. Shapiro, J. Moreland, A.P. Koretsky
    Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imaging, Journal of Biomedical Optics 12: -(2007)
    16. Link to PubMed
  16. G. Pelled, K. Chuang, S.J. Dodd, A.P. Koretsky
    Functional MRI Detection of Bilateral Cortical Reorganization in the Rodent Brain Following Peripheral Nerve Deafferentation, NeuroImage 37: 262-273(2007)
    17. Link to PubMed
  17. A.C. Silva, A.P. Koretsky, J.H. Duyn
    Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex, Magnetic Resonance in Medicine 57: 1110-1118(2007)
    18. Link to PubMed
  18. G. Goelman, G. Pelled, S.J. Dodd, A.P. Koretsky
    Observation of two distinct spatial-temporal BOLD clusters during sensory stimulation in rats, NeuroImage 34: 1220-1226(2007)
    19. Link to PubMed
  19. S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky
    BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system, Magnetic Resonance in Medicine 55: 316-324(2006)
    20. Link to PubMed
  20. G. Pelled, S.J. Dodd, A.P. Koretsky
    Catheter confocal fluorescence imaging and functional magnetic resonance imaging of local and systems level recovery in the regenerating rodent sciatic nerve, NeuroImage 30: 847-856(2006)
    21. Abstract   PDF Full Text
  21. I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. Koretsky
    Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride, NMR in Biomedicine 19: 50-59(2006)
    22. Link to PubMed
  22. O. Rodriguez, S. Fricke, C. Chien, L. Dettin, J. Vanmeter, E.M. Shapiro, H. Dai, M. Casimiro, L. Ileva, J. Dagata, M.D. Johnson, M.P. Lisanti, A.P. Koretsky, C. Albanese
    Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI, Cell Cycle 5: 113-119(2006)
    23. Abstract   PDF Full Text
  23. T. Li, P. van Gelderen, H. Merkle, L.S. Talagala, A.P. Koretsky, J.H. Duyn
    Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T, NeuroImage 32: 1032-1040(2006)
    24. Link to PubMed
  24. K. Chuang, A.P. Koretsky
    Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping, Magnetic Resonance in Medicine 55: 604-611(2006)
    25. Abstract   PDF Full Text
  25. E.M. Shapiro, K. Sharer, S. Skrtic, A.P. Koretsky
    In vivo detection of single cells by MRI, Magnetic Resonance in Medicine 55: 242-249(2006)
    26. Abstract   PDF Full Text
  26. G. Goelman, G. Pelled, S.J. Dodd, A.P. Koretsky
    Observation of two distinct spatial-temporal BOLD clusters during sensory stimulation in rats., NeuroImage : -(2006)

  27. U. Himmelreich, R. Weber, P. Ramos-cabrer, S. Wegener, K. Kandal, E.M. Shapiro, A.P. Koretsky, M. Hoehn
    Improved stem cell MR detectability in animal models by modification of the inhalation gas, Molecular Imaging 4: 104-109(2005)
    28. Abstract   
  28. T.C. Hu, T.F. Christian, A.H. Aletras, J.L. Taylor, A.P. Koretsky, A.E. Arai
    Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart, Magnetic Resonance in Medicine 54: 196-200(2005)
    29. Abstract   PDF Full Text
  29. J. Lee, A.C. Silva, H. Merkle, A.P. Koretsky
    Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast, Magnetic Resonance in Medicine 53: 640-648(2005)
    30. Link to PubMed
  30. A.P. Koretsky, L.S. Talagala, S.D. Keilholz, A.C. Silva
    MRI detection of regional blood flow using arterial spin labeling, Cambridge University Press : 119-140(2005)
  31. O. Speer, N. Back, T. Buerklen, D. Brdiczka, A.P. Koretsky, T. Wallimann, O. Eriksson
    Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membranes, Biochem J 385: 445-450(2005)
    32. Abstract   PDF Full Text
  32. C. Du, A.P. Koretsky, I. Izrailtyan, H. Benveniste
    Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence, Journal of Cerebral Blood Flow and Metabolism : 1-15(2005)
    33. Abstract   PDF Full Text
  33. C. Du, A.P. Koretsky, I. Izrailtyan, H. Benveniste
    Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using photospectrometry, Journal of Cerebral Blood Flow and Metabolism 25: 1078-1092(2005)
  34. E.M. Shapiro, S. Skrtic, A.P. Koretsky
    Sizing it up: cellular MRI using micron-sized iron oxide particles, Magnetic Resonance in Medicine 53: 329-338(2005)
    35. Link to PubMed
  35. J.H. Duyn, P. van Gelderen, L.S. Talagala, A.P. Koretsky, J.A. de Zwart
    Technological advances in MRI measurement of brain perfusion, Journal of Magnetic Resonance Imaging 22: 751-753(2005)
    36. Abstract   PDF Full Text
  36. J.A. de Zwart, A.C. Silva, P. van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A.P. Koretsky, J.A. Frank, J.H. Duyn
    Temporal dynamics of the BOLD fMRI impulse response, NeuroImage 24: 667-677(2005)
    37. Link to PubMed
  37. C. Du, Y. Pan, G.A. MacGowan, A.P. Koretsky
    Decreasing motion artifacts in calcium-dependent fluorescence transients from the perfused mouse heart using frequency filtering, Cell Calcium 35: 144-156(2004)
    38. Abstract   PDF Full Text
  38. S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky
    Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging, Magnetic Resonance in Medicine 52: 89-99(2004)
    39. Link to PubMed
  39. I. Aoki, Y.L. Wu, A.C. Silva, R.M. Lynch, A.P. Koretsky
    In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI, NeuroImage 22: 1046-1059(2004)
    40. Link to PubMed
  40. J. Lee, A.P. Koretsky
    Manganese enhanced magnetic resonance imaging, Current Pharmaceutical Biotechnology 5: 529-537(2004)
    41. Abstract   PDF Full Text
  41. A.C. Silva, J. Lee, I. Aoki, A.P. Koretsky
    Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations,  NMR in Biomedicine 17: 532-543(2004)
    42. Link to PubMed
  42. A.P. Koretsky, A.C. Silva
    Manganese-enhanced magnetic resonance imaging (MEMRI), NMR in Biomedicine 17: 527-531(2004)
    43. Abstract   PDF Full Text
  43. E.M. Shapiro, S. Skrtic, K. Sharer, J.M. Hill, C.E. Dunbar, A.P. Koretsky
    MRI detection of single particles for cellular imaging, Proc. Natl. Acad. Sci. 101: 10901-10906(2004)
    44. Abstract   PDF Full Text
  44. A.P. Koretsky
    New Developments in Magnetic Resonance Imaging of the Brain, NeuroRx : The Journal of the American Society for Experimental NeuroTherapeutics 1: 155-164(2004)
    45. Abstract   PDF Full Text
  45. G.A. MacGowan, C. Evans, T.C. Hu, D. Debrah, S. Mullet, H. Chen, C.F. Mctiernan, A.F. Stewart, A.P. Koretsky, S.G. Shroff
    Troponin I protein kinase c phosphorylation sites and ventricular function, Cardiovascular research 63: 245-255(2004)
    46. Abstract   
  46. K.A. Hinds, J.M. Hill, E.M. Shapiro, M.O. Laukkanen, A.C. Silva, C.A. Combs, T.R. Varney, R.S. Balaban, A.P. Koretsky, D.E. Cynthia
    Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells, Blood 102: 144-156(2003)
    47. Link to PubMed
  47. C. Grabill, A.C. Silva, S.S. Smith, A.P. Koretsky, T.A. Rouault
    MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice, Brain Research 971: 144-156(2003)
    48. Link to PubMed
  48. E.L. Barbier, E. Grillon, A.P. Koretsky, K.S. St. lawrence
    A Model of Blood-Brain Barrier Permeability to Water: Accounting for Blood Inflow and Longitudinal Relaxation Effects,  Magnetic Resonance in Medicine 47: 144-156(2002)
    49. Link to PubMed
  49. D.E. Montgomery, B.M. Wolska, W.G. Pyle, B.B. Roman, J.C. Dowell, P.M. Buttrick, A.P. Koretsky, P. Del nido, R.J. Solaro
    Alpha-Adrenergic Response and Myofilament Activity in Mouse Hearts Lacking PKC Phosphorylation Sites on Cardiac TnI, American Journal Physiology - Heart and Circulatory Physiology 282: 144-156(2002)
    50. Link to PubMed
  50. S.J. Dodd, D.S. Williams, C. Olsen, A.C. Silva, A.P. Koretsky, C. Ho
    An open transverse z-gradient coil designs for magnetic resonance imaging, Rev. Sci. Instru. 73: 2208-2210(2002)
  51. I. Aoki, C. Tanaka, T. Takegami, T. Ebisu, M. Umeda, M. Fukunaga, K. Fukuda, A.C. Silva, A.P. Koretsky, S. Naruse
    Dynamic Activity-Induced Manganese-Dependent Contrast Magnetic Resonance Imaging (DAIM MRI), Magnetic Resonance in Medicine 48: 144-156(2002)
    52. Link to PubMed
  52. A.P. Koretsky
    Functional assessment of tissues with magnetic resonance imaging, Annals of the New York Academy of Sciences 961: 144-156(2002)
    53. Abstract   PDF Full Text
  53. E.L. Barbier, S. Marrett, A. Danek, A. Vortmeyer, P. van Gelderen, J.H. Duyn, P.A. Bandettini, J. Grafman, A.P. Koretsky
    Imaging Cortical Anatomy by High Resolution MR at 3.0T: Detection of the Stripe of Gennari in Visual Area 17,  Magnetic Resonance in Medicine 48: 144-156(2002)
    54. Link to PubMed
  54. A.C. Silva, A.P. Koretsky
    Laminar Specificity of fMRI Onset Times During Somatosensory Stimulation in the Rat, Proc. Natl. Acad. Sci. 99: 144-156(2002)
    55. Link to PubMed
  55. C. Du, Y. Pan, G.A. MacGowan, A.P. Koretsky
    Separation of Calcium Transients and Motion Artifact Using Frequency Filtering of Fluorescent Signals Arising from the Perfused Mouse Heart, Proc. SPIE : 144-156(2002)
  56. R.G. Pautler, A.P. Koretsky
    Tracing Odor Induced Activation in the Olfactory Bulbs of Mice Using Manganese Enhanced Magnetic Resonance Imaging, NeuroImage 16: 144-156(2002)
    57. Link to PubMed
  57. N. Askenasy, A.P. Koretsky
    Transgenic Livers Expressing Mitochondrial and Cytosolic CK: Mitochondrial CK modulates free ADP levels,  American Journal Physiology - Cell Physiology 282: 144-156(2002)
    58. Link to PubMed
  58. G.A. MacGowan, C. Du, D.F. Wieczorek, A.P. Koretsky
    Compensatory Changes in Ca2+ and Myocardial O2 Consumption in β-tropomyosin Transgenic Hearts, American Journal Physiology - Heart and Circulatory Physiology 281: 144-156(2001)
    59. Link to PubMed
  59. G.A. MacGowan, C. Du, A.P. Koretsky
    High Calcium and Dobutamine Positive Inotropy in the Perfused Heart: Myofilament calcium responsiveness, energetic Economy, and effects of protein Kinase C inhibition,  BMC Physiology 1: 144-156(2001)
    60. Link to PubMed
  60. A.J. Wiethoff, J.R. Harkema, A.P. Koretsky, W.E. Brown
    Identification of Mucosal Injury in the Murine Nasal Airways by Magnetic Resonance Imaging: Site specific lesions induced by 3-methylindole,  Toxicology and Applied Pharmacology 175: 144-156(2001)
    61. Link to PubMed
  61. T.C. Hu, R.G. Pautler, G.A. MacGowan, A.P. Koretsky
    Manganese-enhanced MRI of mouse heart during changes in inotropy, Magnetic Resonance in Medicine 46: 144-156(2001)
    62. Abstract   PDF Full Text
  62. E.L. Barbier, A.C. Silva, S. Kim, A.P. Koretsky
    Perfusion Imaging Using Dynamic Arterial Spin Labeling(DASL), Magnetic Resonance in Medicine 45: 144-156(2001)
    63. Link to PubMed
  63. N. Askenasy, A.P. Koretsky
    Transgenic Livers Expressing Mitochondrial and Cytosolic Creatine Kinase: Mitochondrial Creatine Kinase Modulates Free ADP Levels, American Journal Physiology 282: 144-156(2001)
    64. Link to PubMed
  64. G.A. MacGowan, A.P. Koretsky
    Inotropic and Energetic Effects of Altering the Force-Calcium Relationship: Mechanisms, Experimental Results, and Potential Molecular Targets,  Journal of Cardiac Failure 6: 144-156(2000)
    65. Link to PubMed
  65. J.F. Watchko, M.F. Daood, B. Weiringa, A.P. Koretsky
    Myofibrillar or Mitochondrial Creatine Kinase Deficiency Alone does not Impair Mouse Diaphragm Isotonic Function, J. Appl. Physiol. 88: 144-156(2000)
  66. S.J. Dodd, M. Williams, J. Suhan, D.S. Williams, A.P. Koretsky, C. Ho
    Detection of single mammalian cells by high-resolution magnetic resonance imaging, Biophys J. 76: 103-109(1999)
  67. E.L. Barbier, A.C. Silva, H. Kim, D. Will, A.P. Koretsky
    Perfusion Analysis Using Dynamic Arterial Spin Labeling, Magnetic Resonance in Medicine 41: 144-156(1999)
    68. Link to PubMed
  68. D.J. Grandis, G.A. MacGowan, A.P. Koretsky
    Comparison of the Effects of ORG 30029, dobutamine and high perfusate calcium on function and metabolism in rat heart, Journal of Molecular and Cellular Cardiology 30: 2605-2612(1998)
    69. Abstract   PDF Full Text
  69. A.P. Koretsky
    Insights Into Cellular Energy Metabolism from Transgenic Mice, Physiological Reviews 75: 144-156(1995)
    70. Link to PubMed
  70. C.J. Eskey, A.P. Koretsky, M.M. Domach, R.K. Jain
    Role of Oxygen vs. Glucose in Energy Metabolism in a Mammary Carcinoma Perfused ex Vivo, Proc. Natl. Acad. Sci. 90: 144-156(1993)
  71. A.P. Koretsky, D.S. Williams
    Application of Localized in Vivo NMR to Whole Organ Physiology in the Animal, Annual Review of Physiology  54: 144-156(1992)
  72. A.P. Koretsky
    Investigation of Cell Physiology in the Animal Using Transgenic Technology, American Journal Physiology 262: 144-156(1992)
  73. D.S. Williams, J.A. Detre, J.S. Leigh, A.P. Koretsky
    Magnetic Resonance Imaging of Perfusion Using Spin Inversion of Arterial Water, Proc. Natl. Acad. Sci. 89: 144-156(1992)
  74. J.A. Detre, J.S. Leigh, D.S. Williams, A.P. Koretsky
    Perfusion Imaging, Magnetic Resonance in Medicine 23: 144-156(1992)
  75. M.J. Brosnan, L. Chen, T. Van dyke, A.P. Koretsky
    Free ADP levels in Transgenic Mouse Liver Expressing Creatine kinase, Journal of Biological Chemistry 265: 144-156(1990)
  76. J.A. Detre, C.J. Eskey, A.P. Koretsky
    Measurement of Cerebral Bolld Flow in Rat Brain by 19F-NMR Detection of Trifluoromethane Washout, Magnetic Resonance in Medicine 15: 144-156(1990)
  77. A.P. Koretsky, M.J. Brosnan, L. Chen, J. Chen, T. Van dyke
    NMR Detection of Creatine Kinase Expressed in Liver of Transgenic Mice, Proc. Natl. Acad. Sci. 87: 144-156(1990)
  78. A.P. Koretsky, R.S. Balaban
    Determination of Pyridine Nucleotide Fluorescence from the Perfused Heart Using an Internal Standard, American Journal Physiology 253: 144-156(1987)

Curriculum Vitae ro Resume
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